Target “undruggable” membrane proteins even when the binding surface area is very limited – determine the critical residues for binding to inform Ab engineering against rare targets
Map native-state, conformational epitopes in seconds to ensure you get every antibody binding site, including those for low-affinity Abs – labeling occurs on the µs timescale, capturing fleeting interactions
Capture conformational changes indicative of antibody agonist or antagonist behavior to confirm data from cell-based reporter assays – also, assess conformational changes with/without antibody to perform activity screens
Other Services
Protein Small Molecule Interaction
Gain detailed insights into - ligand-protein interactions.
Pinpoint amino acid level hotspots to locate binding interactions.
Generate a detailed map of ligand-induced higher-order structural changes.
Protein-Protein Interaction
Map the specific regions of interactions between proteins.
Characterize drug/receptor interactions, protein aggregation, or dimerization.
Protein Higher Order Structure
Characterize and detect subtle differences in protein higher order structure (HOS).
Use HOS for measuring comparability studies for characterizing biosimilar-innovator differences, expression platforms, formulation, or changes based on buffer or environmental conditions.
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Target “undruggable” membrane proteins even when the binding surface area is very limited – determine the critical residues for binding to inform Ab engineering against rare targets
Map native-state, conformational epitopes in seconds to ensure you get every antibody binding site, including those for low-affinity Abs – labeling occurs on the µs timescale, capturing fleeting interactions
Capture conformational changes indicative of antibody agonist or antagonist behavior to confirm data from cell-based reporter assays – also, assess conformational changes with/without antibody to perform activity screens
